Klobecort Cream is indicated for the relief of non-infective inflammatory and pruritic manifestations of cortico-steroid responsive dermatoses e.g. allergic skin diseases like psoriasis, eczemas and others. Apply in thin film to the affected skin area, 1-2 times a day. Each gram contains 0,5mg Clobetasol Propionate. Clobetasol Propionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.